Optimization of the in vitro oxidative biotransformation of glimepiride as a model substrate for cytochrome p450 using factorial design

BACKGROUND AND PURPOSE OF THE STUDY: Glimepiride (GLM) was chosen as a model substrate in order to determine the kinetic parameters for in vitro metabolism via human liver micrososmes (HLM). We aimed to optimize the turnover of the substrate by the test system in relation to incubation time and HLM...

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Detalles Bibliográficos
Autores principales: Ruikar, Dipti B, Rajput, Sadhana J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555947/
https://www.ncbi.nlm.nih.gov/pubmed/23351782
http://dx.doi.org/10.1186/2008-2231-20-38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555947/
https://www.ncbi.nlm.nih.gov/pubmed/23351782
http://dx.doi.org/10.1186/2008-2231-20-38

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