Effects of IMOD™ and Angipars™ on mouse D-galactose-induced model of aging

The aim of this study was to evaluate the effects of two registered herbal drugs called IMOD and Angipars on mouse model. Aging was induced by D-galactose (500 mg/kg) administered to animals for 6 weeks through drinking water. Male BALB/c mice were randomly divided into 5 groups receiving D-galactos...

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Autores principales: Ghanbari, Samane, Yonessi, Mahsa, Mohammadirad, Azadeh, Gholami, Mahdi, Baeeri, Maryam, Khorram-Khorshid, Hamid Reza, Gharibdoost, Farhad, Abdollahi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555951/
https://www.ncbi.nlm.nih.gov/pubmed/23351487
http://dx.doi.org/10.1186/2008-2231-20-68
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author Ghanbari, Samane
Yonessi, Mahsa
Mohammadirad, Azadeh
Gholami, Mahdi
Baeeri, Maryam
Khorram-Khorshid, Hamid Reza
Gharibdoost, Farhad
Abdollahi, Mohammad
author_facet Ghanbari, Samane
Yonessi, Mahsa
Mohammadirad, Azadeh
Gholami, Mahdi
Baeeri, Maryam
Khorram-Khorshid, Hamid Reza
Gharibdoost, Farhad
Abdollahi, Mohammad
author_sort Ghanbari, Samane
collection PubMed
description The aim of this study was to evaluate the effects of two registered herbal drugs called IMOD and Angipars on mouse model. Aging was induced by D-galactose (500 mg/kg) administered to animals for 6 weeks through drinking water. Male BALB/c mice were randomly divided into 5 groups receiving D-galactose (D-galactose, 500 mg/kg) for 6 weeks; positive control (D-galactose [500 mg/kg] for 6 weeks + Vitamin E [200 mg/kg/day] intraperitoneally for 4 weeks); IMOD (D-galactose [500 mg/kg] for 6 weeks + IMOD [20 mg/kg/day] intraperitoneally for 4 weeks), Angipars (D-galactose [500 mg/kg] for 6 weeks + Angipars [2.1 mg/kg/day] by gavage for 4 weeks); and the fifth group that was sham and not given D-galactose. At the end of treatment, pro-inflammatory markers including tumor necrosis factor-α (TNF-α), interlukine-1β (IL-β), interlukine-6 (IL-6), Nuclear Factor-kappaB (NF-κb), total antioxidant power (TAP), lipid peroxides (LPO) and male sex hormones i.e. testosterone and dehydroepiandrosterone-sulfate (DHEA-S) were measured in the blood. Results showed that D-Galactose induces a significant oxidative stress and proinflammatory cascade of aging while both IMOD and Angipars recovered all of them. Interestingly, IMOD and Angipars were better than Vitamin E in improving male sex hormones in aged mice. This effect is so important and should be considered as an advantage although it cannot be explained with current knowledge. The conclusion is that IMOD and Angipars have marked anti-aging effect on D-galactose-induced model of aging.
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spelling pubmed-35559512013-01-31 Effects of IMOD™ and Angipars™ on mouse D-galactose-induced model of aging Ghanbari, Samane Yonessi, Mahsa Mohammadirad, Azadeh Gholami, Mahdi Baeeri, Maryam Khorram-Khorshid, Hamid Reza Gharibdoost, Farhad Abdollahi, Mohammad Daru Research Article The aim of this study was to evaluate the effects of two registered herbal drugs called IMOD and Angipars on mouse model. Aging was induced by D-galactose (500 mg/kg) administered to animals for 6 weeks through drinking water. Male BALB/c mice were randomly divided into 5 groups receiving D-galactose (D-galactose, 500 mg/kg) for 6 weeks; positive control (D-galactose [500 mg/kg] for 6 weeks + Vitamin E [200 mg/kg/day] intraperitoneally for 4 weeks); IMOD (D-galactose [500 mg/kg] for 6 weeks + IMOD [20 mg/kg/day] intraperitoneally for 4 weeks), Angipars (D-galactose [500 mg/kg] for 6 weeks + Angipars [2.1 mg/kg/day] by gavage for 4 weeks); and the fifth group that was sham and not given D-galactose. At the end of treatment, pro-inflammatory markers including tumor necrosis factor-α (TNF-α), interlukine-1β (IL-β), interlukine-6 (IL-6), Nuclear Factor-kappaB (NF-κb), total antioxidant power (TAP), lipid peroxides (LPO) and male sex hormones i.e. testosterone and dehydroepiandrosterone-sulfate (DHEA-S) were measured in the blood. Results showed that D-Galactose induces a significant oxidative stress and proinflammatory cascade of aging while both IMOD and Angipars recovered all of them. Interestingly, IMOD and Angipars were better than Vitamin E in improving male sex hormones in aged mice. This effect is so important and should be considered as an advantage although it cannot be explained with current knowledge. The conclusion is that IMOD and Angipars have marked anti-aging effect on D-galactose-induced model of aging. BioMed Central 2012-10-27 /pmc/articles/PMC3555951/ /pubmed/23351487 http://dx.doi.org/10.1186/2008-2231-20-68 Text en Copyright ©2012 Ghanbari et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ghanbari, Samane
Yonessi, Mahsa
Mohammadirad, Azadeh
Gholami, Mahdi
Baeeri, Maryam
Khorram-Khorshid, Hamid Reza
Gharibdoost, Farhad
Abdollahi, Mohammad
Effects of IMOD™ and Angipars™ on mouse D-galactose-induced model of aging
title Effects of IMOD™ and Angipars™ on mouse D-galactose-induced model of aging
title_full Effects of IMOD™ and Angipars™ on mouse D-galactose-induced model of aging
title_fullStr Effects of IMOD™ and Angipars™ on mouse D-galactose-induced model of aging
title_full_unstemmed Effects of IMOD™ and Angipars™ on mouse D-galactose-induced model of aging
title_short Effects of IMOD™ and Angipars™ on mouse D-galactose-induced model of aging
title_sort effects of imod™ and angipars™ on mouse d-galactose-induced model of aging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555951/
https://www.ncbi.nlm.nih.gov/pubmed/23351487
http://dx.doi.org/10.1186/2008-2231-20-68
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