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Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cells

BACKGROUND: Presenilin-1 (PS1) is a transmembrane protein first discovered because of its association with familial Alzheimer’s disease. Mice with null mutations in PS1 die shortly after birth exhibiting multiple CNS and non-CNS abnormalities. One of the most prominent features in the brains of PS1−...

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Detalles Bibliográficos
Autores principales: De Gasperi, Rita, Gama Sosa, Miguel A, Elder, Gregory A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556133/
https://www.ncbi.nlm.nih.gov/pubmed/23259730
http://dx.doi.org/10.1186/1471-2091-13-28