Transgenic Mouse Model with Deficient Mitochondrial Polymerase Exhibits Reduced State IV Respiration and Enhanced Cardiac Fibrosis

Mitochondria produce the energy required for proper cardiac contractile function, and cardiomyocytes that exhibit reduced mitochondrial electron transport will have reduced energy production and decreased contractility. Mitochondrial DNA (mtDNA) encodes the core subunits for the protein complexes of...

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Detalles Bibliográficos
Autores principales: Koczor, Christopher A., Torres, Rebecca A., Fields, Earl, Qin, Qianhong, Park, Jade, Ludaway, Tomika, Russ, Rodney, Lewis, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556371/
https://www.ncbi.nlm.nih.gov/pubmed/23090637
http://dx.doi.org/10.1038/labinvest.2012.146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556371/
https://www.ncbi.nlm.nih.gov/pubmed/23090637
http://dx.doi.org/10.1038/labinvest.2012.146

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