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Size-Exclusion Chromatography for the Analysis of Protein Biotherapeutics and their Aggregates
In recent years, the use and number of biotherapeutics has increased significantly. For these largely protein-based therapies, the quantitation of aggregates is of particular concern given their potential effect on efficacy and immunogenicity. This need has renewed interest in size-exclusion chromat...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556795/ https://www.ncbi.nlm.nih.gov/pubmed/23378719 http://dx.doi.org/10.1080/10826076.2012.743724 |