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Overexpression of MyrAkt1 in Endothelial Cells Leads to Erythropoietin- and BMP4-Independent Splenic Erythropoiesis in Mice

Under steady state conditions, erythropoiesis occurs in the bone marrow. However, in mice, stress or tissue hypoxia results in increased erythropoiesis in the spleen. There is increasing evidence that the hematopoietic microenvironment, including endothelial cells, plays an important role in regulat...

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Detalles Bibliográficos
Autores principales: O’Donnell, Rebekah K., Goldstein, Whitney E., Perruzzi, Carole, Benjamin, Laura E., Aird, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557261/
https://www.ncbi.nlm.nih.gov/pubmed/23383068
http://dx.doi.org/10.1371/journal.pone.0055095