Sodium Valproate Alleviates Neurodegeneration in SCA3/MJD via Suppressing Apoptosis and Rescuing the Hypoacetylation Levels of Histone H3 and H4

Spinocerebellar ataxia type 3 (SCA3) also known as Machado-Joseph Disease (MJD), is one of nine polyglutamine (polyQ) diseases caused by a CAG-trinucelotide repeat expansion within the coding sequence of the ATXN3 gene. There are no disease-modifying treatments for polyQ diseases. Recent studies sug...

Descripción completa

Detalles Bibliográficos
Autores principales: Yi, Jiping, Zhang, Li, Tang, Beisha, Han, Weiwei, Zhou, Yafang, Chen, Zhao, Jia, Dandan, Jiang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557284/
https://www.ncbi.nlm.nih.gov/pubmed/23382971
http://dx.doi.org/10.1371/journal.pone.0054792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557284/
https://www.ncbi.nlm.nih.gov/pubmed/23382971
http://dx.doi.org/10.1371/journal.pone.0054792

Ejemplares similares