Cargando…

Identification of Inhibitor Binding Site in Human Sirtuin 2 Using Molecular Docking and Dynamics Simulations

The ability to identify the site of a protein that can bind with high affinity to small, drug-like compounds has been an important goal in drug design. Sirtuin 2 (SIRT2), histone deacetylase protein family, plays a central role in the regulation of various pathways. Hence, identification of drug for...

Descripción completa

Detalles Bibliográficos
Autores principales: Sakkiah, Sugunadevi, Arooj, Mahreen, Kumar, Manian Rajesh, Eom, Soo Hyun, Lee, Keun Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557295/
https://www.ncbi.nlm.nih.gov/pubmed/23382805
http://dx.doi.org/10.1371/journal.pone.0051429