Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells

There is growing evidence that aminobisphosphonates like ibandronate show anticancer activity by an unknown mechanism. Biochemically, they prevent posttranslational isoprenylation of small GTPases, thus inhibiting their activity. In tumor cells, activated RAS-GTPase, the founding member of the gene...

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Detalles Bibliográficos
Autores principales: Thaler, R., Spitzer, S., Karlic, H., Berger, C., Klaushofer, K., Varga, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557391/
https://www.ncbi.nlm.nih.gov/pubmed/23103563
http://dx.doi.org/10.1016/j.bcp.2012.10.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557391/
https://www.ncbi.nlm.nih.gov/pubmed/23103563
http://dx.doi.org/10.1016/j.bcp.2012.10.016

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