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Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells
There is growing evidence that aminobisphosphonates like ibandronate show anticancer activity by an unknown mechanism. Biochemically, they prevent posttranslational isoprenylation of small GTPases, thus inhibiting their activity. In tumor cells, activated RAS-GTPase, the founding member of the gene...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557391/ https://www.ncbi.nlm.nih.gov/pubmed/23103563 http://dx.doi.org/10.1016/j.bcp.2012.10.016 |