Toward Rational Fragment-Based Lead Design without 3D Structures

[Image: see text] Fragment-based lead discovery (FBLD) has become a prime component of the armamentarium of modern drug design programs. FBLD identifies low molecular weight ligands that weakly bind to important biological targets. Three-dimensional structural information about the binding mode is p...

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Detalles Bibliográficos
Autores principales: Henen, Morkos A., Coudevylle, Nicolas, Geist, Leonhard, Konrat, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557921/
https://www.ncbi.nlm.nih.gov/pubmed/22889313
http://dx.doi.org/10.1021/jm301016m

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557921/
https://www.ncbi.nlm.nih.gov/pubmed/22889313
http://dx.doi.org/10.1021/jm301016m

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