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Toward Rational Fragment-Based Lead Design without 3D Structures
[Image: see text] Fragment-based lead discovery (FBLD) has become a prime component of the armamentarium of modern drug design programs. FBLD identifies low molecular weight ligands that weakly bind to important biological targets. Three-dimensional structural information about the binding mode is p...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557921/ https://www.ncbi.nlm.nih.gov/pubmed/22889313 http://dx.doi.org/10.1021/jm301016m |