Comparison of treatment effect sizes associated with surrogate and final patient relevant outcomes in randomised controlled trials: meta-epidemiological study

Objective To quantify and compare the treatment effect and risk of bias of trials reporting biomarkers or intermediate outcomes (surrogate outcomes) versus trials using final patient relevant primary outcomes. Design Meta-epidemiological study. Data sources All randomised clinical trials published i...

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Detalles Bibliográficos
Autores principales: Ciani, Oriana, Buyse, Marc, Garside, Ruth, Pavey, Toby, Stein, Ken, Sterne, Jonathan A C, Taylor, Rod S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558411/
https://www.ncbi.nlm.nih.gov/pubmed/23360719
http://dx.doi.org/10.1136/bmj.f457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558411/
https://www.ncbi.nlm.nih.gov/pubmed/23360719
http://dx.doi.org/10.1136/bmj.f457

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