Cargando…

Contrasting Properties of α7-Selective Orthosteric and Allosteric Agonists Examined on Native Nicotinic Acetylcholine Receptors

Subtype-selective ligands are important tools for the pharmacological characterisation of neurotransmitter receptors. This is particularly the case for nicotinic acetylcholine receptors (nAChRs), given the heterogeneity of their subunit composition. In addition to agonists and antagonists that inter...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gill, JasKiran K., Chatzidaki, Anna, Ursu, Daniel, Sher, Emanuele, Millar, Neil S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558472/ https://www.ncbi.nlm.nih.gov/pubmed/23383051 http://dx.doi.org/10.1371/journal.pone.0055047

Ejemplares similares

The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors
por: Chatzidaki, Anna, et al.
Publicado: (2015)

Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking Cessation
por: Mohamed, Tasnim S., et al.
Publicado: (2015)

Structurally Similar Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors Exhibit Five Distinct Pharmacological Effects
por: Gill-Thind, JasKiran K., et al.
Publicado: (2015)

Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models
por: Kryukova, Elena V., et al.
Publicado: (2018)

Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons
por: Chatzidaki, Anna, et al.
Publicado: (2015)

FRET-Based Detection of M(1) Muscarinic Acetylcholine Receptor Activation by Orthosteric and Allosteric Agonists
por: Markovic, Danijela, et al.
Publicado: (2012)

Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model
por: Newcombe, Joseph, et al.
Publicado: (2018)

Differential Contribution of Subunit Interfaces to α9α10 Nicotinic Acetylcholine Receptor Function
por: Boffi, Juan Carlos, et al.
Publicado: (2017)

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107
por: Mizrachi, Tehila, et al.
Publicado: (2021)

Bitopic ligands: all-in-one orthosteric and allosteric
por: Kamal, Maud, et al.
Publicado: (2009)

Assessing the Binding of Venoms from Aquatic Elapids to the Nicotinic Acetylcholine Receptor Orthosteric Site of Different Prey Models
por: Harris, Richard J., et al.
Publicado: (2020)

Activation of the Rat α1β2ε GABA(A) Receptor by Orthosteric and Allosteric Agonists
por: Germann, Allison L., et al.
Publicado: (2022)

5-HT(2C) Receptor Stimulation in Obesity Treatment: Orthosteric Agonists vs. Allosteric Modulators
por: Przegaliński, Edmund, et al.
Publicado: (2023)

Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists
por: Zheng, Yi, et al.
Publicado: (2016)

Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators
por: Jakubík, Jan, et al.
Publicado: (2019)

Orthosteric and allosteric modulation of human HCAR2 signaling complex
por: Mao, Chunyou, et al.
Publicado: (2023)

Multitargeting nature of muscarinic orthosteric agonists and antagonists
por: Myslivecek, Jaromir
Publicado: (2022)

Assessing potentiation of the (α4)3(β2)2 nicotinic acetylcholine receptor by the allosteric agonist CMPI
por: Deba, Farah, et al.
Publicado: (2021)

Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators
por: Manetti, Dina, et al.
Publicado: (2023)

Differential regulation of muscarinic M(1 )receptors by orthosteric and allosteric ligands
por: Davis, Christopher N, et al.
Publicado: (2009)

Cooperativity between the orthosteric and allosteric ligand binding sites of RORγt
por: de Vries, Rens M. J. M., et al.
Publicado: (2021)

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor
por: Spurny, Radovan, et al.
Publicado: (2015)

On-target and off-target effects of novel orthosteric and allosteric activators of GPR84
por: Mancini, Sarah J., et al.
Publicado: (2019)

Orthosteric–allosteric dual inhibitors of PfHT1 as selective antimalarial agents
por: Huang, Jian, et al.
Publicado: (2021)

New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2
por: Ferrisi, Rebecca, et al.
Publicado: (2023)

An allosteric link connecting the lipid-protein interface to the gating of the nicotinic acetylcholine receptor
por: Domville, Jaimee A., et al.
Publicado: (2018)

An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein
por: Delbart, Florian, et al.
Publicado: (2018)

TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors
por: Wall, Teagan R., et al.
Publicado: (2017)

Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor
por: Smelt, Charles L.C., et al.
Publicado: (2018)

Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists
por: Ajram, Laura, et al.
Publicado: (2014)

Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition
por: Kennedy, Amanda J., et al.
Publicado: (2020)

Orthosteric and Allosteric Dual Targeting of the Nuclear Receptor RORγt with a Bitopic Ligand
por: Meijer, Femke A., et al.
Publicado: (2021)

Molecular Modeling Study of a Receptor–Orthosteric Ligand–Allosteric Modulator Signaling Complex
por: Jiang, Chen, et al.
Publicado: (2023)

Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2
por: Cheng, Lin, et al.
Publicado: (2023)

The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis
por: Bakhtyukov, Andrey A., et al.
Publicado: (2021)

Menthol Suppresses Nicotinic Acetylcholine Receptor Functioning in Sensory Neurons via Allosteric Modulation
por: Hans, M., et al.
Publicado: (2012)

Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors
por: Ho, Thao NT, et al.
Publicado: (2023)

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M(4) mAChR
por: Burger, Wessel A. C., et al.
Publicado: (2023)

The effective opening of nicotinic acetylcholine receptors with single agonist binding sites
por: Williams, Dustin K., et al.
Publicado: (2011)

Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors
por: Choudhary, Shivani, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0nt6etlasl3a5qvbnr7r0vqqh1