Pharmacokinetics, pharmacodynamics and efficacy of novel FabI inhibitor AFN-1252 against MSSA and MRSA in the murine thigh infection model

AFN-1252, a new antimicrobial agent, specifically and potently inhibits fatty acid synthesis in Staphylococcus aureus. We characterized in vivo pharmacokinetic and pharmacodynamic profiles of AFN-1252 administered orally to neutropenic mice inoculated in thighs (∼10(6) CFU) with methicillin-suscepti...

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Detalles Bibliográficos
Autores principales: Banevicius, Mary A, Kaplan, Nachum, Hafkin, Barry, Nicolau, David P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Maney Publishing 2013
Materias:
Antimicrobial Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558988/
https://www.ncbi.nlm.nih.gov/pubmed/23433441
http://dx.doi.org/10.1179/1973947812Y.0000000061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558988/
https://www.ncbi.nlm.nih.gov/pubmed/23433441
http://dx.doi.org/10.1179/1973947812Y.0000000061

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