Deficiency in MyD88 Signaling Results in Decreased Antibody Responses to an Adeno-Associated Virus Vector in Murine Pompe Disease

We have previously shown that antibody and T cell responses limit the efficacy of an adeno-associated virus (AAV) pseudotype 8 (2/8) vector containing the universally active cytomegalovirus enhancer/chicken β-actin regulatory cassette (AAV2/8-CBhGAA) in treating murine Pompe disease. However, the in...

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Detalles Bibliográficos
Autores principales: Zhang, Ping, Luo, Xiaoyan, Bird, Andrew, Li, Songtao, Koeberl, Dwight D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559236/
https://www.ncbi.nlm.nih.gov/pubmed/23514839
http://dx.doi.org/10.1089/biores.2012.0217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559236/
https://www.ncbi.nlm.nih.gov/pubmed/23514839
http://dx.doi.org/10.1089/biores.2012.0217

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