Brain Region Specific Pre-Synaptic and Post-Synaptic Degeneration Are Early Components of Neuropathology in Prion Disease

Synaptic abnormalities, one of the key features of prion disease pathogenesis, gives rise to functional deficits and contributes to the devastating clinical outcome. The synaptic compartment is the first to succumb in several neurodegenerative diseases linked with protein misfolding but the mechanis...

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Detalles Bibliográficos
Autores principales: Šišková, Zuzana, Reynolds, Richard A., O’Connor, Vincent, Perry, V. Hugh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559345/
https://www.ncbi.nlm.nih.gov/pubmed/23383030
http://dx.doi.org/10.1371/journal.pone.0055004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559345/
https://www.ncbi.nlm.nih.gov/pubmed/23383030
http://dx.doi.org/10.1371/journal.pone.0055004

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