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Repair of DNA Strand Breaks in a Minichromosome In Vivo: Kinetics, Modeling, and Effects of Inhibitors

To obtain an overall picture of the repair of DNA single and double strand breaks in a defined region of chromatin in vivo, we studied their repair in a ∼170 kb circular minichromosome whose length and topology are analogous to those of the closed loops in genomic chromatin. The rate of repair of si...

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Detalles Bibliográficos
Autores principales: Kumala, Slawomir, Fujarewicz, Krzysztof, Jayaraju, Dheekollu, Rzeszowska-Wolny, Joanna, Hancock, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559499/
https://www.ncbi.nlm.nih.gov/pubmed/23382828
http://dx.doi.org/10.1371/journal.pone.0052966