Blockade of Kv1.3 Potassium Channels Inhibits Differentiation and Granzyme B Secretion of Human CD8+ T Effector Memory Lymphocytes

Increased expression of the voltage-gated potassium channel Kν1.3 on activated effector memory T cells (T(EM)) is associated with pathology in multiple sclerosis (MS). To date, most studies of Kν1.3 channels in MS have focused on CD4+ T(EM) cells. Much less is known about the functional relevance of...

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Detalles Bibliográficos
Autores principales: Hu, Lina, Wang, Tongguang, Gocke, Anne R., Nath, Avindra, Zhang, Hao, Margolick, Joseph B., Whartenby, Katharine A., Calabresi, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559683/
https://www.ncbi.nlm.nih.gov/pubmed/23382885
http://dx.doi.org/10.1371/journal.pone.0054267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559683/
https://www.ncbi.nlm.nih.gov/pubmed/23382885
http://dx.doi.org/10.1371/journal.pone.0054267

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