Long-term channelrhodopsin-2 (ChR2) expression can induce abnormal axonal morphology and targeting in cerebral cortex

Long-term expression of optogenetic proteins including channelrhodopsin-2 (ChR2) is widely used to study neural circuit function, but whether ChR2 expression itself perturbs circuits is not known. We expressed a common construct, CAG::ChR2 (H134R)-EYFP-WPRE, in L2/3 pyramidal cells in rat somatosens...

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Detalles Bibliográficos
Autores principales: Miyashita, Toshio, Shao, Yu R., Chung, Jason, Pourzia, Olivia, Feldman, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560348/
https://www.ncbi.nlm.nih.gov/pubmed/23386813
http://dx.doi.org/10.3389/fncir.2013.00008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560348/
https://www.ncbi.nlm.nih.gov/pubmed/23386813
http://dx.doi.org/10.3389/fncir.2013.00008

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