Depletion of nuclear histone H2A variants is associated with chronic DNA damage signaling upon drug-evoked senescence of human somatic cells

Cellular senescence is associated with global chromatin changes, altered gene expression, and activation of chronic DNA damage signaling. These events ultimately lead to morphological and physiological transformations in primary cells. In this study, we show that chronic DNA damage signals caused by...

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Detalles Bibliográficos
Autores principales: Lopez, Mary F., Tollervey, James, Krastins, Bryan, Garces, Alejandra, Sarracino, David, Prakash, Amol, Vogelsang, Maryann, Geesman, Glenn, Valderrama, Augusto, Jordan, I. King, Lunyak, Victoria V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560435/
https://www.ncbi.nlm.nih.gov/pubmed/23235539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560435/
https://www.ncbi.nlm.nih.gov/pubmed/23235539

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