Osthole, a herbal compound, alleviates nucleus pulposus-evoked nociceptive responses through the suppression of overexpression of acid-sensing ion channel 3 (ASIC3) in rat dorsal root ganglion

BACKGROUND: Osthole (Ost), a natural coumarin derivative, has been shown to inhibit many pro-inflammatory mediators and block voltage-gated Na(+) channels. During inflammation, acidosis is an important pain inducer which activates nociceptors by gating depolarizing cationic channels, such as acid-se...

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Detalles Bibliográficos
Autores principales: He, Qiu-Lan, Chen, Yuling, Qin, Jian, Mo, Sui-Lin, Wei, Ming, Zhang, Jin-Jun, Li, Mei-Na, Zou, Xue-Nong, Zhou, Shu-Feng, Chen, Xiao-Wu, Sun, Lai-Bao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2012
Materias:
Basic Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560735/
https://www.ncbi.nlm.nih.gov/pubmed/22648244
http://dx.doi.org/10.12659/MSM.882899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560735/
https://www.ncbi.nlm.nih.gov/pubmed/22648244
http://dx.doi.org/10.12659/MSM.882899

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