Synthesis and biological evaluation of propargyl acetate derivatives as anti-mycobacterial agents

BACKGROUND: The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which Mtb is resistant to conventional drug therapies, is of particular...

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Detalles Bibliográficos
Autores principales: Azerang, Parisa, Rezayan, Ali Hossein, Sardari, Soroush, Kobarfard, Farzad, Bayat, Mitra, Tabib, Kimia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561248/
https://www.ncbi.nlm.nih.gov/pubmed/23351675
http://dx.doi.org/10.1186/2008-2231-20-90
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author Azerang, Parisa
Rezayan, Ali Hossein
Sardari, Soroush
Kobarfard, Farzad
Bayat, Mitra
Tabib, Kimia
author_facet Azerang, Parisa
Rezayan, Ali Hossein
Sardari, Soroush
Kobarfard, Farzad
Bayat, Mitra
Tabib, Kimia
author_sort Azerang, Parisa
collection PubMed
description BACKGROUND: The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which Mtb is resistant to conventional drug therapies, is of particular interest. METHODS: This study is focused on propargyl acetate derivatives. Eight molecules were designed based on propargyl alcohols and different acid anhydrides. RESULTS: All the synthesized compounds and commercially available ones were evaluated for anti-tuberculosis activity. CONCLUSIONS: Inhibitors against Mtb have been identified and characterized for further development into potential novel anti-tubercular drugs.
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spelling pubmed-35612482013-02-04 Synthesis and biological evaluation of propargyl acetate derivatives as anti-mycobacterial agents Azerang, Parisa Rezayan, Ali Hossein Sardari, Soroush Kobarfard, Farzad Bayat, Mitra Tabib, Kimia Daru Research Article BACKGROUND: The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which Mtb is resistant to conventional drug therapies, is of particular interest. METHODS: This study is focused on propargyl acetate derivatives. Eight molecules were designed based on propargyl alcohols and different acid anhydrides. RESULTS: All the synthesized compounds and commercially available ones were evaluated for anti-tuberculosis activity. CONCLUSIONS: Inhibitors against Mtb have been identified and characterized for further development into potential novel anti-tubercular drugs. BioMed Central 2012-12-11 /pmc/articles/PMC3561248/ /pubmed/23351675 http://dx.doi.org/10.1186/2008-2231-20-90 Text en Copyright ©2012 Azerang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Azerang, Parisa
Rezayan, Ali Hossein
Sardari, Soroush
Kobarfard, Farzad
Bayat, Mitra
Tabib, Kimia
Synthesis and biological evaluation of propargyl acetate derivatives as anti-mycobacterial agents
title Synthesis and biological evaluation of propargyl acetate derivatives as anti-mycobacterial agents
title_full Synthesis and biological evaluation of propargyl acetate derivatives as anti-mycobacterial agents
title_fullStr Synthesis and biological evaluation of propargyl acetate derivatives as anti-mycobacterial agents
title_full_unstemmed Synthesis and biological evaluation of propargyl acetate derivatives as anti-mycobacterial agents
title_short Synthesis and biological evaluation of propargyl acetate derivatives as anti-mycobacterial agents
title_sort synthesis and biological evaluation of propargyl acetate derivatives as anti-mycobacterial agents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561248/
https://www.ncbi.nlm.nih.gov/pubmed/23351675
http://dx.doi.org/10.1186/2008-2231-20-90
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