Integrity of p53 Associated Pathways Determines Induction of Apoptosis of Tumor Cells Resistant to Aurora-A Kinase Inhibitors

We have previously shown that mammary tumorigenesis in MMTV-Aurora-A mice is further enhanced when p53 is inactivated, demonstrating that integrity of p53 pathway determines phenotypes induced by this oncogenic kinase. In this study, we investigated the roles of genes involved in p53 pathway (p53, P...

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Detalles Bibliográficos
Autores principales: Shionome, Yoshimi, Yan, Li, Liu, Song, Saeki, Toshiaki, Ouchi, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561291/
https://www.ncbi.nlm.nih.gov/pubmed/23383195
http://dx.doi.org/10.1371/journal.pone.0055457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561291/
https://www.ncbi.nlm.nih.gov/pubmed/23383195
http://dx.doi.org/10.1371/journal.pone.0055457

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