The Oxidative Modification of Von Willebrand Factor Is Associated with Thrombotic Angiopathies in Diabetes Mellitus

The thrombogenic activity of Von Willebrand factor (VWF) is proportional to its molecular size and inversely related to its proteolysis by ADAMTS-13. Oxidation of VWF severely impairs its proteolysis by the metalloprotease. This study was aimed at assessing in patients with type 1 and type 2 diabete...

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Detalles Bibliográficos
Autores principales: Oggianu, Laura, Lancellotti, Stefano, Pitocco, Dario, Zaccardi, Francesco, Rizzo, Paola, Martini, Francesca, Ghirlanda, Giovanni, De Cristofaro, Raimondo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561310/
https://www.ncbi.nlm.nih.gov/pubmed/23383177
http://dx.doi.org/10.1371/journal.pone.0055396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561310/
https://www.ncbi.nlm.nih.gov/pubmed/23383177
http://dx.doi.org/10.1371/journal.pone.0055396

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