Deletion of the LTR Enhancer/Promoter Has No Impact on the Integration Profile of MLV Vectors in Human Hematopoietic Progenitors

Moloney murine leukemia virus (MLV)-derived gamma-retroviral vectors integrate preferentially near transcriptional regulatory regions in the human genome, and are associated with a significant risk of insertional gene deregulation. Self-inactivating (SIN) vectors carry a deletion of the U3 enhancer...

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Detalles Bibliográficos
Autores principales: Moiani, Arianna, Miccio, Annarita, Rizzi, Ermanno, Severgnini, Marco, Pellin, Danilo, Suerth, Julia Debora, Baum, Christopher, De Bellis, Gianluca, Mavilio, Fulvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561312/
https://www.ncbi.nlm.nih.gov/pubmed/23383272
http://dx.doi.org/10.1371/journal.pone.0055721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561312/
https://www.ncbi.nlm.nih.gov/pubmed/23383272
http://dx.doi.org/10.1371/journal.pone.0055721

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