A Novel Retro-Inverso Peptide Inhibitor Reduces Amyloid Deposition, Oxidation and Inflammation and Stimulates Neurogenesis in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease

Previously, we have developed a retro-inverso peptide inhibitor (RI-OR2, rGffvlkGr) that blocks the in vitro formation and toxicity of the Aβ oligomers which are thought to be a cause of neurodegeneration and memory loss in Alzheimer’s disease. We have now attached a retro-inverted version of the HI...

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Detalles Bibliográficos
Autores principales: Parthsarathy, Vadivel, McClean, Paula L., Hölscher, Christian, Taylor, Mark, Tinker, Claire, Jones, Glynn, Kolosov, Oleg, Salvati, Elisa, Gregori, Maria, Masserini, Massimo, Allsop, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561363/
https://www.ncbi.nlm.nih.gov/pubmed/23382963
http://dx.doi.org/10.1371/journal.pone.0054769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561363/
https://www.ncbi.nlm.nih.gov/pubmed/23382963
http://dx.doi.org/10.1371/journal.pone.0054769

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