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Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

Normal axonal mitochondrial transport and function is essential for the maintenance of synaptic function. Abnormal mitochondrial motility and mitochondrial dysfunction within axons are critical for amyloid β (Aβ)-induced synaptic stress and the loss of synapses relevant to the pathogenesis of Alzhei...

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Detalles Bibliográficos
Autores principales: Guo, Lan, Du, Heng, Yan, Shiqiang, Wu, Xiaoping, McKhann, Guy M., Chen, John Xi, Yan, Shirley ShiDu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561411/
https://www.ncbi.nlm.nih.gov/pubmed/23382999
http://dx.doi.org/10.1371/journal.pone.0054914