Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

Cellular senescence both protects multicellular organisms from cancer and contributes to their aging(1). The preeminent tumor suppressor p53 plays an important role in the induction and maintenance of senescence, but how p53 carries out this function remains poorly understood(1–3). Additionally, whi...

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Detalles Bibliográficos
Autores principales: Jiang, Peng, Du, Wenjing, Mancuso, Anthony, Wellen, Kathryn E., Yang, Xiaolu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561500/
https://www.ncbi.nlm.nih.gov/pubmed/23334421
http://dx.doi.org/10.1038/nature11776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561500/
https://www.ncbi.nlm.nih.gov/pubmed/23334421
http://dx.doi.org/10.1038/nature11776

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