Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists

The TSHR (thyrotropin receptor) is activated endogenously by the large hormone thyrotropin and activated pathologically by auto-antibodies. Both activate and bind at the extracellular domain. Recently, SMLs (small-molecule ligands) have been identified, which bind in an allosteric binding pocket wit...

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Detalles Bibliográficos
Autores principales: Hoyer, Inna, Haas, Ann-Karin, Kreuchwig, Annika, Schülein, Ralf, Krause, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Biochemical Society Focused Meetings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561627/
https://www.ncbi.nlm.nih.gov/pubmed/23356285
http://dx.doi.org/10.1042/BST20120319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561627/
https://www.ncbi.nlm.nih.gov/pubmed/23356285
http://dx.doi.org/10.1042/BST20120319

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