Pharmacokinetic Interaction Between Prasugrel and Ritonavir in Healthy Volunteers

The new anti-aggregating agent prasugrel is bioactivated by cytochromes P450 (CYP) 3A and 2B6. Ritonavir is a potent CYP3A inhibitor and was shown in vitro as a CYP2B6 inhibitor. The aim of this open-label cross-over study was to assess the effect of ritonavir on prasugrel active metabolite (prasugr...

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Detalles Bibliográficos
Autores principales: Ancrenaz, Virginie, Déglon, Julien, Samer, Caroline, Staub, Christian, Dayer, Pierre, Daali, Youssef, Desmeules, Jules
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561686/
https://www.ncbi.nlm.nih.gov/pubmed/22900583
http://dx.doi.org/10.1111/j.1742-7843.2012.00932.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561686/
https://www.ncbi.nlm.nih.gov/pubmed/22900583
http://dx.doi.org/10.1111/j.1742-7843.2012.00932.x

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