Inhibition of the EGF Receptor by Binding to an Activating Kinase Domain Interface

Members of the epidermal growth factor receptor family (EGFR/Erb1, Erb2/HER2, ErbB3/HER3 and ErbB4/HER4) are key targets for inhibition in cancer therapy(1). Critical for activation is the formation of an asymmetric dimer by the intracellular kinase domains, in which the C-terminal lobe (C-lobe) of...

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Detalles Bibliográficos
Autores principales: Zhang, Xuewu, Pickin, Kerry A., Bose, Ron, Jura, Natalia, Cole, Philip A., Kuriyan, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561764/
https://www.ncbi.nlm.nih.gov/pubmed/18046415
http://dx.doi.org/10.1038/nature05998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561764/
https://www.ncbi.nlm.nih.gov/pubmed/18046415
http://dx.doi.org/10.1038/nature05998

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