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Inhibition of the EGF Receptor by Binding to an Activating Kinase Domain Interface

Members of the epidermal growth factor receptor family (EGFR/Erb1, Erb2/HER2, ErbB3/HER3 and ErbB4/HER4) are key targets for inhibition in cancer therapy(1). Critical for activation is the formation of an asymmetric dimer by the intracellular kinase domains, in which the C-terminal lobe (C-lobe) of...

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Detalles Bibliográficos
Autores principales:	Zhang, Xuewu, Pickin, Kerry A., Bose, Ron, Jura, Natalia, Cole, Philip A., Kuriyan, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2007
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561764/ https://www.ncbi.nlm.nih.gov/pubmed/18046415 http://dx.doi.org/10.1038/nature05998

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