Molecular mechanisms that control the expression and activity of Bcl-6 in T(H)1 cells to regulate flexibility with a T(FH)-like gene profile

T-bet and Bcl-6 are required to establish T(H)1 or T(FH) gene expression profiles, respectively. Here, we demonstrated that high interleukin 2 (IL-2) concentrations inhibited Bcl-6 expression in polarized T(H)1 cells. Mechanistically, the low amounts of Bcl-6 normally found in effector T(H)1 cells c...

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Detalles Bibliográficos
Autores principales: Oestreich, Kenneth J., Mohn, Sarah E., Weinmann, Amy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561768/
https://www.ncbi.nlm.nih.gov/pubmed/22406686
http://dx.doi.org/10.1038/ni.2242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561768/
https://www.ncbi.nlm.nih.gov/pubmed/22406686
http://dx.doi.org/10.1038/ni.2242

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