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Molecular mechanisms that control the expression and activity of Bcl-6 in T(H)1 cells to regulate flexibility with a T(FH)-like gene profile
T-bet and Bcl-6 are required to establish T(H)1 or T(FH) gene expression profiles, respectively. Here, we demonstrated that high interleukin 2 (IL-2) concentrations inhibited Bcl-6 expression in polarized T(H)1 cells. Mechanistically, the low amounts of Bcl-6 normally found in effector T(H)1 cells c...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561768/ https://www.ncbi.nlm.nih.gov/pubmed/22406686 http://dx.doi.org/10.1038/ni.2242 |