Correlated alterations in genome organization, histone methylation, and DNA–lamin A/C interactions in Hutchinson-Gilford progeria syndrome

Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease that is frequently caused by a de novo point mutation at position 1824 in LMNA. This mutation activates a cryptic splice donor site in exon 11, and leads to an in-frame deletion within the prelamin A mRNA and the production of...

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Detalles Bibliográficos
Autores principales: McCord, Rachel Patton, Nazario-Toole, Ashley, Zhang, Haoyue, Chines, Peter S., Zhan, Ye, Erdos, Michael R., Collins, Francis S., Dekker, Job, Cao, Kan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561867/
https://www.ncbi.nlm.nih.gov/pubmed/23152449
http://dx.doi.org/10.1101/gr.138032.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561867/
https://www.ncbi.nlm.nih.gov/pubmed/23152449
http://dx.doi.org/10.1101/gr.138032.112

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