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Integration of the metabolic/redox state, histone gene switching, DNA replication and S-phase progression by moonlighting metabolic enzymes

The concept of one-protein–multiple-function, i.e. moonlighting proteins, is an ever-expanding paradigm. We obtained compelling evidence that an array of ‘cytoplasmic’ metabolic enzymes can enter the nuclei to carry out moonlighting transcription functions; this phenomenon is conserved from Drosophi...

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Detalles Bibliográficos
Autores principales: He, Hongpeng, Lee, Mei-Chin, Zheng, Li-Ling, Zheng, Lei, Luo, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561917/
https://www.ncbi.nlm.nih.gov/pubmed/23134369
http://dx.doi.org/10.1042/BSR20120059