Deregulation of poly(A) polymerase I in Escherichia coli inhibits protein synthesis and leads to cell death

Polyadenylation plays important roles in RNA metabolism in both prokaryotes and eukaryotes. Surprisingly, deregulation of polyadenylation by poly(A) polymerase I (PAP I) in Escherichia coli leads to toxicity and cell death. We show here that mature tRNAs, which are normally not substrates for PAP I...

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Detalles Bibliográficos
Autores principales: Mohanty, Bijoy K., Kushner, Sidney R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561954/
https://www.ncbi.nlm.nih.gov/pubmed/23241393
http://dx.doi.org/10.1093/nar/gks1280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561954/
https://www.ncbi.nlm.nih.gov/pubmed/23241393
http://dx.doi.org/10.1093/nar/gks1280

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