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Deregulation of poly(A) polymerase I in Escherichia coli inhibits protein synthesis and leads to cell death
Polyadenylation plays important roles in RNA metabolism in both prokaryotes and eukaryotes. Surprisingly, deregulation of polyadenylation by poly(A) polymerase I (PAP I) in Escherichia coli leads to toxicity and cell death. We show here that mature tRNAs, which are normally not substrates for PAP I...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561954/ https://www.ncbi.nlm.nih.gov/pubmed/23241393 http://dx.doi.org/10.1093/nar/gks1280 |