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AT-rich sequence elements promote nascent transcript cleavage leading to RNA polymerase II termination

RNA Polymerase II (Pol II) termination is dependent on RNA processing signals as well as specific terminator elements located downstream of the poly(A) site. One of the two major terminator classes described so far is the Co-Transcriptional Cleavage (CoTC) element. We show that homopolymer A/T tract...

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Detalles Bibliográficos
Autores principales: White, Eleanor, Kamieniarz-Gdula, Kinga, Dye, Michael J., Proudfoot, Nick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561976/
https://www.ncbi.nlm.nih.gov/pubmed/23258704
http://dx.doi.org/10.1093/nar/gks1335