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Volatility in mRNA secondary structure as a design principle for antisense

Designing effective antisense sequences is a formidable problem. A method for predicting efficacious antisense holds the potential to provide fundamental insight into this biophysical process. More practically, such an understanding increases the chance of successful antisense design as well as savi...

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Detalles Bibliográficos
Autores principales: Johnson, Erik, Srivastava, Ranjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562002/
https://www.ncbi.nlm.nih.gov/pubmed/23161691
http://dx.doi.org/10.1093/nar/gks902