Reduction in ATP Levels Triggers Immunoproteasome Activation by the 11S (PA28) Regulator during Early Antiviral Response Mediated by IFNβ in Mouse Pancreatic β-Cells

Autoimmune destruction of insulin producing pancreatic β-cells is the hallmark of type I diabetes. One of the key molecules implicated in the disease onset is the immunoproteasome, a protease with multiple proteolytic sites that collaborates with the constitutive 19S and the inducible 11S (PA28) act...

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Detalles Bibliográficos
Autores principales: Freudenburg, Wieke, Gautam, Madhav, Chakraborty, Pradipta, James, Jared, Richards, Jennifer, Salvatori, Alison S., Baldwin, Aaron, Schriewer, Jill, Buller, R. Mark L, Corbett, John A., Skowyra, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562186/
https://www.ncbi.nlm.nih.gov/pubmed/23383295
http://dx.doi.org/10.1371/journal.pone.0052408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562186/
https://www.ncbi.nlm.nih.gov/pubmed/23383295
http://dx.doi.org/10.1371/journal.pone.0052408

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