Frequency and Prognostic Impact of CEBPA Proximal, Distal and Core Promoter Methylation in Normal Karyotype AML: A Study on 623 Cases

The clinical impact of aberrant CEBPA promoter methylation (PM) in AML is controversially discussed. The aim of this study was to clarify the significance of aberrant CEBPA PM with regard to clinical features in a cohort of 623 cytogenetically normal (CN) de novo AML. 555 cases had wild-type CEBPA,...

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Detalles Bibliográficos
Autores principales: Fasan, Annette, Alpermann, Tamara, Haferlach, Claudia, Grossmann, Vera, Roller, Andreas, Kohlmann, Alexander, Eder, Christiane, Kern, Wolfgang, Haferlach, Torsten, Schnittger, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562230/
https://www.ncbi.nlm.nih.gov/pubmed/23383300
http://dx.doi.org/10.1371/journal.pone.0054365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562230/
https://www.ncbi.nlm.nih.gov/pubmed/23383300
http://dx.doi.org/10.1371/journal.pone.0054365

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