Cancerous Inhibitor of Protein Phosphatase 2A Mediates Bortezomib-Induced Autophagy in Hepatocellular Carcinoma Independent of Proteasome

Previously, we reported that cancerous inhibitor of protein phosphatase 2A (CIP2A) mediates the apoptotic effect of bortezomib in hepatocellular carcinoma (HCC). Here, we report a proteasome-independent mechanism by which bortezomib induces autophagy in HCC. Our data indicate that bortezomib activat...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Hui-Chuan, Hou, Duen-Ren, Liu, Chun-Yu, Lin, Chen-Si, Shiau, Chung-Wai, Cheng, Ann-Lii, Chen, Kuen-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562236/
https://www.ncbi.nlm.nih.gov/pubmed/23383345
http://dx.doi.org/10.1371/journal.pone.0055705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562236/
https://www.ncbi.nlm.nih.gov/pubmed/23383345
http://dx.doi.org/10.1371/journal.pone.0055705

Ejemplares similares