The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome

Fibroblasts derived from the progeroid Werner syndrome (WS) show reduced replicative lifespan and a “stressed” morphology, both phenotypes being alleviated by using the p38 MAP kinase inhibitor SB203580. Because p38 is a major hub for the control of stress-signalling pathways we were interested in e...

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Detalles Bibliográficos
Autores principales: Davis, Terence, Rokicki, Michal J, Bagley, Mark C, Kipling, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562269/
https://www.ncbi.nlm.nih.gov/pubmed/23360642
http://dx.doi.org/10.1186/1752-153X-7-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562269/
https://www.ncbi.nlm.nih.gov/pubmed/23360642
http://dx.doi.org/10.1186/1752-153X-7-18

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