p53 can repress transcription of cell cycle genes through a p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements

The tumor suppressor p53 plays an important role in cell cycle arrest by downregulating transcription. Many genes repressed by p53 code for proteins with functions in G₂/M. A large portion of these genes is controlled by cell cycle-dependent elements (CDE) and cell cycle genes homology regions (CHR)...

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Detalles Bibliográficos
Autores principales: Quaas, Marianne, Müller, Gerd A., Engeland, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562311/
https://www.ncbi.nlm.nih.gov/pubmed/23187802
http://dx.doi.org/10.4161/cc.22917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562311/
https://www.ncbi.nlm.nih.gov/pubmed/23187802
http://dx.doi.org/10.4161/cc.22917

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