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Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain

Mitochondrial maintenance crucially depends on the quality control of proteins by various chaperones, proteases and repair enzymes. While most of the involved components have been studied in some detail, little is known on the biological role of the CLPXP protease complex located in the mitochondria...

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Detalles Bibliográficos
Autores principales: Fischer, Fabian, Weil, Andrea, Hamann, Andrea, Osiewacz, Heinz D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562451/
https://www.ncbi.nlm.nih.gov/pubmed/23360988
http://dx.doi.org/10.1038/ncomms2397