Multiple pore conformations driven by asynchronous movements of voltage sensors in a eukaryotic sodium channel

Voltage-dependent Na(+) channels are crucial for electrical signalling in excitable cells. Membrane depolarization initiates asynchronous movements in four non-identical voltage-sensing domains of the Na(+) channel. It remains unclear to what extent this structural asymmetry influences pore gating a...

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Detalles Bibliográficos
Autores principales: Goldschen-Ohm, Marcel P., Capes, Deborah L., Oelstrom, Kevin M., Chanda, Baron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562458/
https://www.ncbi.nlm.nih.gov/pubmed/23322038
http://dx.doi.org/10.1038/ncomms2356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562458/
https://www.ncbi.nlm.nih.gov/pubmed/23322038
http://dx.doi.org/10.1038/ncomms2356

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