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Multiple pore conformations driven by asynchronous movements of voltage sensors in a eukaryotic sodium channel
Voltage-dependent Na(+) channels are crucial for electrical signalling in excitable cells. Membrane depolarization initiates asynchronous movements in four non-identical voltage-sensing domains of the Na(+) channel. It remains unclear to what extent this structural asymmetry influences pore gating a...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562458/ https://www.ncbi.nlm.nih.gov/pubmed/23322038 http://dx.doi.org/10.1038/ncomms2356 |