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Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels

Small- and intermediate-conductance Ca(2+)-activated potassium channels, activated by Ca(2+)-bound calmodulin, play an important role in regulating membrane excitability. These channels are also linked to clinical abnormalities. A tremendous amount of effort has been devoted to developing small mole...

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Detalles Bibliográficos
Autores principales: Zhang, Miao, Pascal, John M., Schumann, Marcel, Armen, Roger S., Zhang, Ji-fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563359/
https://www.ncbi.nlm.nih.gov/pubmed/22929778
http://dx.doi.org/10.1038/ncomms2017